It took several years, but a research team headed by Professor Jens Nielsen at Chalmers University of Technology has finally succeeded in mapping out the complex metabolism of yeast cells. The breakthrough, recently published in an article in Nature Communications, means a huge step forward in the potential to more efficiently produce protein therapies for diseases such as cancer.
The market for pharmaceuticals that mimic the body’s own proteins – protein-based therapeutics – is exploding. Some of them are relatively simple to manufacture in yeast-based cell factories. Insulin and HPV vaccine are two examples that are already under production, but other therapies, such as antibodies to various forms of cancer, are significantly more difficult to manufacture.
“They are currently produced using a cell factory based on a single cell from a Chinese hamster. It’s an extremely expensive process. If we can get yeast cells to do the same thing, it will be …